Abortività ricorrente

Farmacogenetica

Studio delle varianti genetiche che influenzano la risposta ai trattamenti farmacologici.

Avanzato test genetico che permette di prevedere la risposta del paziente ai particolare farmaci. I clinici potranno utilizzare l’informazione derivante dal test per personalizzare la terapia in base al profilo genetico del paziente, individuando il farmaco più appropriato e il relativo dosaggio ottimale, evitando il lungo processo di adattamento della terapia e il rischio di tossicità.

Gene Count List of genes Notes
18 CHE, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A5, CYP4F2, DPYD, G6PD, HLA-B, IFNL4, NAT2, NUDT15, RYR1, SLCO1B1, TPMT, UGT1A1, VKORC1 Pharmacogenetic (PGx) tests gives clinicians the tools to better understand how their patients will respond to certain medications. With PGx testing, it’s possible to tailor medication plans to a patient’s specific genetic makeup. This can lead to reduced medical costs for patients and providers, safer medication plans, and more efficient drug efficacy. The PGx Focus Panel includes genes associated with drug metabolism with high-level evidence and clinically actionable guidelines.
PGx testing can reveal if a person is a fast, normal, or slow metabolizer. A person’s metabolism changes the way their body responds to medication, including:
• Toxicity
Excessive amounts of the drug accumulate in the bloodstream, resulting in ADRs.
• Lack of Efficacy
The bloodstream cannot absorb enough of the drug to achieve a therapeutic effect.
• Hypersensitivity
Normal amounts of the drug enter the bloodstream, but even this is enough to trigger severe reactions in people with hypersensitivity to the medication.
Potential benefits for patients
Identify which drug may be most effective before treatment starts
PGx testing can help clinicians choose the most effective drug for each patient, minimize the risk of adverse reactions, and reduce hospitalizations.
Reduce the risk of adverse events related to certain drugs
PGx testing can assess a patient’s risk for adverse drug reactions before they take the medication which can improve patient safety and minimize costs for healthcare facilities.
Adjust and optimize the dose of current medications
PGx testing can help clinicians predict the appropriate dose of medication for their patient. This allows them to create more personalized medication plans to maximize efficacy and reduce pharmacy costs.
Improved Patient Care
PGx test results become part of a patient’s medical record, allowing physicians to make more informed decisions when prescribing medications for future medical issues.

Gene Count List of genes Notes
44 ABCB1, ACE, ANKK1, APOE, ATM, BCHE, CES1, COMT, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, CYP3A5, CYP4F2, DPYD, DRD2, ERCC1, F2, F5, G6PD, GGCX, GRIK4, GSTP1, HLA-B, HTR1A, HTR2A, HTR2C, IFNL4, ITPA, KIF6, MTHFR, NAT2, NQO1, NUDT15, OPRM1, RYR1, SLCO1B1, TPMT, UGT1A1, UGT1A4, VKORC1, XRCC1 Pharmacogenetic (PGx) tests gives clinicians the tools to better understand how their patients will respond to certain medications.
With PGx testing, it’s possible to tailor medication plans to a patient’s specific genetic makeup. This can lead to reduced medical costs for patients and providers, safer medication plans, and more efficient drug efficacy. The PGx Comprehensive Panel includes genes associated with drug metabolism with high level evidence and clinically actionable guidelines, in addition to genes with PharmGKB evidence of 2 or higher. Evidence for these associations are significant, but not as high as those in the focused panel.
PGx testing can reveal if a person is a fast, normal, or slow metabolizer. A person’s metabolism changes the way their body responds to medication, including:
• Toxicity
Excessive amounts of the drug accumulate in the bloodstream, resulting in ADRs.
• Lack of Efficacy
The bloodstream cannot absorb enough of the drug to achieve a therapeutic effect.
• Hypersensitivity
Normal amounts of the drug enter the bloodstream, but even this is enough to trigger severe reactions in people with hypersensitivity to the medication.
Potential benefits for patients
Identify which drug may be most effective before treatment starts
PGx testing can help clinicians choose the most effective drug for each patient, minimize the risk of adverse reactions, and reduce hospitalizations.
Reduce the risk of adverse events related to certain drugs
PGx testing can assess a patient’s risk for adverse drug reactions before they take the medication which can improve patient safety and minimize costs for healthcare facilities.
Adjust and optimize the dose of current medications
PGx testing can help clinicians predict the appropriate dose of medication for their patient. This allows them to create more personalized medication plans to maximize efficacy and
reduce pharmacy costs.
Improved Patient Care
PGx test results become part of a patient’s medical record, allowing physicians to make more informed decisions when prescribing medications for future medical issues.

Gene Count List of genes Notes
4 CYP2C9, CYP2D6, CYP2C19, VKORC1 An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
5 CYP1A2, CYP2C9, CYP2C19, CYP2D6, 5HTT An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
3 CYP3A4, CYP3A5, CYP3A7 An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
25 ABCC2 (Metabolism methotrexate), ABCB1 (Metabolism taxan derived drugs), ABL, ADRB2, CYP3A4 (Metabolism taxan derived drugs), CYP3A5 (Metabolism taxan derived drugs), DPYD (Metabolism FLUOROPYRIMIDINES drugs), EGFR, ERCC1 (Metabolism platinum derived drugs), FLT3, GSTP1, GSTP1 (Metabolism platinum derived drugs), KIT, MDR1, PDGFRA, RAD51, TPMT, TS, TSER (Metabolism FLUOROPYRIMIDINES drugs), UGT1A1, UGT1A6, UGT1A7, UGT1A9, XRCC1 (Metabolism platinum derived drugs), XRCC3. An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
5 ABCC2 (Metabolism methotrexate), ABCB1 (Metabolism taxan derived drugs), ABL, ADRB2, CYP3A4 (Metabolism taxan derived drugs), CYP3A5 (Metabolism taxan derived drugs), DPYD (Metabolism FLUOROPYRIMIDINES drugs), EGFR, ERCC1 (Metabolism platinum derived drugs), FLT3, GSTP1, GSTP1 (Metabolism platinum derived drugs), KIT, MDR1, PDGFRA, RAD51, TPMT, TS, TSER (Metabolism FLUOROPYRIMIDINES drugs), UGT1A1, UGT1A6, UGT1A7, UGT1A9, XRCC1 (Metabolism platinum derived drugs), XRCC3. An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
5 CYP1A2, CYP2C9, CYP3A4, CYP3A5, CYP3A7 An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
4 CYP2D6, CYP3A4, CYP3A5, CYP3A7 An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
3 GSTP1, XRCC1, ERCC1 An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
3 TYMS, DPD, MTHFR An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
4 ABCB1, CBR3, SOD2, GSTM1 An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
1 ACYP2D6 An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
4 UGT1A, CYP3A4, CYP3A5, ABCB1 An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
3 MTHFR, TYMS, ABCC2 An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
4 XRCC1, XRCC3, RAD51, GSTP1 An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
3 CYP3A4, CYP3A5, ABCB1 An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
7 CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, CYP3A7 An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
6 CYP1A2, CYP2C9, CYP2C19, CYP3A4, CYP3A5, CYP3A7 An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity..

Gene Count List of genes Notes
7 CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, CYP3A7 An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
1 DRD2 An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
5 CYP2C9, CYP2D6, CYP3A4, CYP3A5, CYP3A7 An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.

Gene Count List of genes Notes
10 CYP2C9, CYP2C19, CYP3A4, CYP3A5, CYP3A7, A2M, COMT, DRD2, FLT3, MDR1 An advanced genetic test that allows to predict the patient's response to particular drugs. Clinicians will be able to use the information deriving from the test to customize the therapy based on the patient's genetic profile, identifying the most appropriate drug and its optimal dosage, avoiding the long process of adapting the therapy and the risk of toxicity.