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cfDNA-based product of conception karyotyping
Dear Customer,
GENOMICA is proud to introduce you POCADVANCE cfDNA, an advanced genetic test that, using groundbreaking technologies, determines the karyotype of product of conception (POC). By analyzing the circulating cell-free fetal DNA (cfDNA) in maternal blood, using the latest fully automated sequencing technologies (Next Generation Sequencing - NGS), it screens for genome-wide numerical and structural chromosomal abnormalities, providing unparalleled accuracy and detection compared to traditional karyotyping.
POCADVANCE cfDNA test is able to provide information on the possible genetic causes of a spontaneous miscarriage, with the aim of helping the couple in family planning with specific reproductive genetic counseling.
During pregnancy, placental trophoblasts releases DNA fragments into the maternal blood, starting from the 5th week of gestation. This DNA is also named circulating cell-free fetal DNA (cfDNA). During miscarriage, the placental tissue continues to release cfDNA into the maternal bloodstream, making it possible to perform early non-invasive investigations, thus obtaining valuable information on the genetic causes of the abortion.
Circulating cell-free DNA is purified from the plasma component of anti-coagulated maternal whole blood sample. Subsequently, the cfDNA is analyzed by means of the innovative sequencing technology named Next Generation Sequencing (NGS). The chromosomal sequences are then quantified through an advanced bioinformatics analysis, in order to detect fetal chromosomal imbalances.
POCADVANCE cfDNATest is intended for patients who meet any of the following criteria:
The test can be performed in case of spontaneous abortions of single or twin pregnancies, monozygotic or dizygotic, with at least 5 weeks of gestation.
It is possible to obtain the POCADVANCE cfDNATest results in about 3 days.
If you are interested to receive a more information on POCADVANCE, we invite you to write to us:
Contact Genomica
Stay tuned, to learn about the most advanced and innovative diagnostic solutions in the genetics field.
GENOMICA srl
Marketing and Communication Department
GENOMICA is proud to introduce you POCADVANCE cfDNA, an advanced genetic test that, using groundbreaking technologies, determines the karyotype of product of conception (POC). By analyzing the circulating cell-free fetal DNA (cfDNA) in maternal blood, using the latest fully automated sequencing technologies (Next Generation Sequencing - NGS), it screens for genome-wide numerical and structural chromosomal abnormalities, providing unparalleled accuracy and detection compared to traditional karyotyping.
POCADVANCE cfDNA test is able to provide information on the possible genetic causes of a spontaneous miscarriage, with the aim of helping the couple in family planning with specific reproductive genetic counseling.
The testing process
During pregnancy, placental trophoblasts releases DNA fragments into the maternal blood, starting from the 5th week of gestation. This DNA is also named circulating cell-free fetal DNA (cfDNA). During miscarriage, the placental tissue continues to release cfDNA into the maternal bloodstream, making it possible to perform early non-invasive investigations, thus obtaining valuable information on the genetic causes of the abortion.
Circulating cell-free DNA is purified from the plasma component of anti-coagulated maternal whole blood sample. Subsequently, the cfDNA is analyzed by means of the innovative sequencing technology named Next Generation Sequencing (NGS). The chromosomal sequences are then quantified through an advanced bioinformatics analysis, in order to detect fetal chromosomal imbalances.
Indications for testing
POCADVANCE cfDNATest is intended for patients who meet any of the following criteria:
- Women who have had a miscarriage or with miscarriage in progress;
- Women who have had recurrent miscarriages;
- Women who have had miscarriages following IVF treatments.
The test can be performed in case of spontaneous abortions of single or twin pregnancies, monozygotic or dizygotic, with at least 5 weeks of gestation.
Turnaround time
It is possible to obtain the POCADVANCE cfDNATest results in about 3 days.
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If you are interested to receive a more information on POCADVANCE, we invite you to write to us:
Contact Genomica
Stay tuned, to learn about the most advanced and innovative diagnostic solutions in the genetics field.
GENOMICA srl
Marketing and Communication Department