EN
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SKINPROFILEGenetic assessment of dermatological and trichological predispositions
A personalised genetic profile for dermatology and trichology, supporting specialist assessment of:
- skin ageing and photodamage
- structural skin characteristics
- skin barrier integrity and hydration
- oxidative stress and glycation
- micronutrient metabolism relevant to skin and hair
- the biological profile of the skin and hair follicle
SKIN AGEING AND INDIVIDUAL VARIABILITY
Skin quality, skin ageing and many aspects of dermatological and trichological physiology arise from a dynamic interaction among genetic background, environmental exposures, lifestyle and nutritional status.
Genetic factors may contribute to inter-individual differences in:
- hydration and skin barrier integrity
- elasticity and the quality of the dermal matrix
- response to oxidative stress
- susceptibility to photodamage
- glycation processes
- the metabolism of vitamins, minerals and essential fatty acids
- specific dermatological and trichological traits
Genetic analysis can identify DNA variants reported in the scientific literature to be associated with skin- and hair-related phenotypes or biological predispositions. These associations are probabilistic and must be interpreted alongside the patient's clinical, environmental and lifestyle context.
THE VALUE OF GENETICS IN PERSONALISED DERMATOLOGY
SKINPROFILE is a targeted genetic test developed by GENOMICA to assess individual predispositions that may influence the physiology of the skin and hair.
The test assesses biological factors involved in skin tissue maintenance, ageing processes, photoprotection, skin barrier homeostasis and the metabolism of vitamins, minerals and essential fatty acids. It is intended to add a stable, personalised layer of information to preventive and specialist evaluation.
PURPOSE OF THE TEST
SKINPROFILE assesses individual genetic predisposition in relation to key parameters relevant to the health and physiological balance of the skin and its appendages, with particular reference to:
- skin hydration and barrier homeostasis
- skin elasticity and structural support
- antioxidant defence
- photoprotection and response to ultraviolet exposure
- glycation-related processes
- the metabolism of micronutrients relevant to skin and hair
SCOPE: The test evaluates predisposition associated with the selected genetic markers. It does not directly measure hydration, collagen, oxidative stress, vitamin or mineral concentrations, or the clinical condition of the skin and hair.
WHO IS IT FOR?
SKINPROFILE is designed for specialist use by physicians and qualified healthcare professionals who wish to integrate genetic information into the evaluation of:
- skin quality and physiology
- early signs of skin ageing
- photoageing and photodamage
- reduced resilience of the epidermal barrier
- skin traits of aesthetic and functional interest
- hair quality and trichological predispositions
- nutritional status and support relevant to the skin, hair and nails
PROFESSIONAL USE: results should be discussed with a qualified healthcare professional and integrated with medical history, examination and any clinically appropriate laboratory tests or other investigations.
PRACTICAL VALUE FOR THE SPECIALIST
SKINPROFILE is not a diagnostic test. It is a clinically informative adjunct designed to support a more comprehensive understanding of the patient's individual profile. It may help the specialist to:
- characterise the biological profile of the skin and its appendages
- identify genetic predispositions that may not be apparent on direct clinical assessment
- inform proportionate, risk-aware dermatological prevention strategies
- support personalised dermocosmetic and nutritional counselling, when clinically appropriate
- integrate genetic findings with medical history, clinical evaluation and environmental context
- facilitate more focused counselling and shared decision-making
In a healthcare setting increasingly focused on personalisation, SKINPROFILE offers an additional level of insight for a more individualised approach to patient management.
KEY PRINCIPLE: Genetic data should complement - never replace - clinical judgement.
WHAT THE TEST ASSESSES
The test covers a broad range of functional areas of dermatological and trichological interest:
Skin ageing
Assessment of genetic predisposition associated with earlier signs of ageing, loss of tone and elasticity, reduced dermal matrix resilience, tissue laxity and other features of structural skin deterioration.
Photodamage and photoprotection
Assessment of individual susceptibility to ultraviolet radiation-related damage, including photoageing, pigmentary changes and other photo-induced effects.
Glycation
Assessment of predisposition to glycation-related processes that may affect collagen and elastin and contribute to the biological mechanisms of skin ageing.
Hydration and skin barrier integrity
Assessment of factors involved in maintaining hydration, softness, barrier function and skin comfort.
Skin elasticity
Assessment of factors involved in dermal integrity, skin tone and the structural support of tissues.
Antioxidant capacity
Assessment of biological susceptibility to oxidative skin damage, relevant to cellular defence and the maintenance of tissue integrity.
Skin characteristics
Analysis of biological traits associated with skin type and selected characteristics of dermatological or aesthetic interest.
Dermatological and trichological traits
Assessment of predisposition relating to selected characteristics of the skin and hair follicles.
Vitamins, minerals and nutrients
Assessment of genetic predisposition associated with inter-individual differences in the metabolism or status of vitamins, minerals, essential fatty acids and other nutrients involved in skin physiology.
IMPORTANT: Results refer to the markers included in the test and do not constitute direct measurements of skin structure or function.
NUTRITIONAL INTERPRETATION: a genetic finding does not demonstrate a nutrient deficiency or justify supplementation on its own. Laboratory testing and clinical assessment remain necessary when deficiency is suspected.
TOWARDS MORE PERSONALISED DERMATOLOGY
Information from SKINPROFILE may help refine the patient's individual profile and support the development of personalised pathways focused on:
Prevention
Dermatological counselling
Dermocosmetic support
Patient education
Considered nutritional integration
Monitoring over time
A STABLE LAYER OF INFORMATION: genetic data do not replace clinical assessment; they can enrich it when interpreted in context. Not every result will require or justify a change in management.
ANALYTICAL WORKFLOW
DNA extraction
Genomic DNA (buccal mucosal cells or peripheral blood)
Target amplification
PCR amplification of the regions containing the variants of interest
Sequencing and genotyping
Advanced technologies, including Next Generation Sequencing (NGS)
Bioinformatic analysis
Dedicated pipelines and interpretive algorithms
Personalised report
Findings and associated genetic predispositions
INTERPRETIVE FRAMEWORK
GENOMICA's interpretive framework is based on the structured selection, appraisal and integration of evidence from peer-reviewed international scientific literature.
Depending on the trait, the assessment may draw on:
- genome-wide association studies (GWAS);
- multivariable analyses of multiple genetic variants;
- univariable studies of individual variants with reported phenotype associations.
Evidence quality, consistency and applicability are considered when interpreting the profile. The test estimates susceptibility within the limits of current knowledge; it does not predict an outcome with certainty.
A SIMPLE FIVE-STEP PROCESS
Request the kit
Complete the documentation
Collect the sample
Send the sample to the laboratory
Receive the report
~10 working daysSkinProfile Brochure
Read the official brochure for the complete test information.
Download the brochure